{"id":808,"date":"2016-09-23T11:42:57","date_gmt":"2016-09-23T11:42:57","guid":{"rendered":"http:\/\/tecnodiabetes.ai2.upv.es\/?page_id=808"},"modified":"2025-08-14T10:10:17","modified_gmt":"2025-08-14T08:10:17","slug":"insulaid2","status":"publish","type":"page","link":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/insulaid2\/","title":{"rendered":"INSULAID2"},"content":{"rendered":"

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PROYECTOS\u00a0<\/span><\/h4>\n

INSULAID2
<\/h3>\n

Control de glucemia en lazo cerrado en pacientes con diabetes mellitus 1 y pacientes Cr\u00edticos<\/span>
<\/p>\n

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Datos administrativos<\/h4>\n

Referencia del proyecto:<\/strong> DPI2007-66728-C02-01
T\u00edtulo:<\/strong> Control de glucemia en lazo cerrado en pacientes con diabetes mellitus 1 y pacientes cr\u00edticos
<\/span>Entidades participantes:<\/strong> Proyecto coordinado
Subproyecto 1:<\/strong> Universitat Polit\u00e8cnica de Val\u00e8ncia (coordinador); Subproyecto 2:<\/strong> Universitat de Girona
<\/span>Investigador principal:<\/strong> Jorge Bondia (coordinador); Josep Veh\u00ed
Entidad financiadora:<\/strong> Ministerio de Educaci\u00f3n y Ciencia
Duraci\u00f3n:<\/strong> 01\/10\/2007-01\/10\/2011
Financiaci\u00f3n recibida:<\/strong> Subproyecto 1: 195.415,00\u20ac;
Subproyecto 2: 206.063,00\u20ac<\/p>\n

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Resumen del proyecto<\/h4>\n

En la d\u00e9cada de los 90, se demostr\u00f3 que cualquier mejora en el control gluc\u00e9mico se traduce en una reducci\u00f3n del riesgo de desarrollar las complicaciones cr\u00f3nicas asociadas a la diabetes. Por esta raz\u00f3n, la normoglucemia se ha convertido en el objetivo de control de los pacientes afectos de diabetes mellitus 1. Por otra parte, el paciente cr\u00edtico en la Unidad de Cuidados Intensivos est\u00e1 sujeto a una gran morbilidad y mortalidad. Los \u00faltimos avances en el conocimiento de la fisiopatolog\u00eda de estos pacientes demuestran como la hiperglucemia puede contribuir sobre la evoluci\u00f3n cl\u00ednica. Existe literatura que orienta hacia la importancia de conseguir normoglucemia en estos pacientes mediante perfusiones de insulina para reducir la mortalidad. Existe por tanto un gran inter\u00e9s social y econ\u00f3mico en el control eficaz de la glucemia.<\/p>\n

Se espera que en 4 o 5 a\u00f1os la tecnolog\u00eda necesaria para un control autom\u00e1tico de la glucemia est\u00e9 disponible, siendo actualmente los sensores continuos de glucosa un factor limitante. Es por tanto de primordial importancia el estudio de algoritmos de control de glucemia eficaces, el desarrollo de buenos modelos del sistema glucorregulatorio y su validaci\u00f3n a partir de criterios terap\u00e9uticos.<\/p>\n

Se plantean por tanto en este proyecto dos objetivos globales: (1) la implementaci\u00f3n de un estudio cl\u00ednico para la obtenci\u00f3n de datos experimentales que permitan el desarrollo de modelos y su validaci\u00f3n terap\u00e9utica; (2) el desarrollo de algoritmos de control avanzados para el control en lazo cerrado de la glucemia en pacientes con DM1 y pacientes cr\u00edticos.<\/p>\n

Se emplear\u00e1n t\u00e9cnicas intervalares y conjuntistas para abordar el problema de la variabilidad intra e interpaciente. Finalmente se explorar\u00e1 el uso de se\u00f1ales contrarreguladoras como el glucag\u00f3n o glucosa adem\u00e1s de la insulina en el control.<\/p>\n

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Investigadores<\/h4>\n

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Universitat Polit\u00e8cnica de Val\u00e8ncia:<\/H6><\/p>\n
    \n
  • Jorge Bondia (coordinador)<\/li>\n
  • Jos\u00e9 Luis D\u00edez<\/li>\n
  • Sergio Romero<\/li>\n
  • Beatriz Ricarte<\/li>\n
  • Cristina Tar\u00edn<\/li>\n
  • F\u00e1tima Barcel\u00f3<\/li>\n
  • Alejandro Laguna<\/li>\n
  • Ana Revert<\/li>\n<\/ul>\n

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    Universitat de Girona<\/strong><\/H6><\/p>\n
      \n
    • Josep Veh\u00ed (co-IP)<\/li>\n
    • Remei Calm<\/li>\n
    • \n

      Miguel \u00c1ngel Sainz<\/p>\n<\/li>\n

    • \n

      Maira Garc\u00eda-Jaramillo<\/p>\n<\/li>\n

    • Fabi\u00e1n Le\u00f3n<\/li>\n
    • Yenny Leal<\/li>\n
    • Cris\u00f3stomo A. Barajas<\/li>\n
    • Darine Zambrano<\/li>\n
    • Winston M. Garc\u00eda Gab\u00edn<\/li>\n
    • Oscar Olarte<\/li>\n<\/ul>\n

      <\/p>\n

        \n<\/ul>\n

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        Hospital Clínico de Valencia<\/h6>\n
          \n
        • F. Javier Ampudia<\/li>\n<\/ul>\n
          Hospital Francesc de Borja de Gandía<\/h6>\n
            \n
          • Paolo Rossetti<\/li>\n<\/ul>\n

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