{"id":3813,"date":"2026-02-02T16:51:23","date_gmt":"2026-02-02T15:51:23","guid":{"rendered":"https:\/\/tecnodiabetes.ai2.upv.es\/?page_id=3813"},"modified":"2026-02-03T20:17:44","modified_gmt":"2026-02-03T19:17:44","slug":"t1sia","status":"publish","type":"page","link":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en","title":{"rendered":"T1SIA"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; fullwidth=\u00bbon\u00bb custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#f15d2f\u00bb custom_padding=\u00bb30px|||\u00bb custom_padding_tablet=\u00bb50px|0|50px|0&#8243; custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bbon\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_fullwidth_code _builder_version=\u00bb4.16&#8243; global_colors_info=\u00bb{}\u00bb].[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||-105px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb1_4,1_2,1_4&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb-43px|auto||auto||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2026\/02\/EN_FundedbytheEU_RGB_POS-scaled.png\u00bb alt=\u00bbMinisterio de Econom\u00eda y c\u00bb title_text=\u00bbEN_FundedbytheEU_RGB_POS\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16&#8243; min_height=\u00bb1535.7px\u00bb custom_padding=\u00bb54px|0px|0px|0px\u00bb custom_padding_tablet=\u00bb50px|0|50px|0&#8243; custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb text_orientation=\u00bbcenter\u00bb module_alignment=\u00bbcenter\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb inline_fonts=\u00bbMontserrat\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4><span style=\"font-family: Montserrat; color: #999999;\">PROJECTS<\/span><\/h4>\n<p>&nbsp;<\/p>\n<h3>T1SIA<\/h3>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: Montserrat; font-size: large;\">TYPE 1 DIABETES SIMULATOR WITH ADJUNCTIVE THERAPIES \u2013 GLP1<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2&#8243; padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2026\/02\/t1sia-logo-big.png\u00bb title_text=\u00bbt1sia-logo-big\u00bb align_tablet=\u00bbcenter\u00bb align_phone=\u00bbcenter\u00bb align_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.27.4&#8243; animation_style=\u00bbslide\u00bb animation_direction=\u00bbleft\u00bb animation_duration=\u00bb500ms\u00bb animation_intensity_slide=\u00bb10%\u00bb hover_enabled=\u00bb0&#8243; animation=\u00bbleft\u00bb sticky=\u00bboff\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb always_center_on_mobile=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4>Administrative Data<\/h4>\n<p><strong>Project Reference:<\/strong> <span>HORIZON-MSCA-2024-PF-01. Proposal number: 101205486<\/span><br \/><strong style=\"font-size: 14px;\">Title:<\/strong><span style=\"font-size: 14px;\"> <span>T1SIA \u2013 Type 1 Diabetes Simulator with Adjunctive therapies \u2013 GLP1<\/span><br \/><\/span><strong style=\"font-size: 14px;\">Participant Entities:<\/strong><span style=\"font-size: 14px;\"> <span>Universitat Polit\u00e8cnica de Val\u00e8ncia, University of Bern<\/span><\/span><span style=\"font-size: 14px;\"><br \/><\/span><strong style=\"font-size: 14px;\">Principal Investigator:<\/strong><span style=\"font-size: 14px;\"> Jorge Bondia<br \/><strong style=\"font-size: 14px;\">Funding Entity:<\/strong><span style=\"font-size: 14px;\"> Uni\u00f3n Europea<br \/><\/span><strong style=\"font-size: 14px;\">Duration:<\/strong><span style=\"font-size: 14px;\"> <span>12\/01\/2026 \u2013 11\/01\/2028<\/span><br \/><\/span><strong style=\"font-size: 14px;\">Funding:<\/strong><span style=\"font-size: 14px;\"> <span>243.096,72 \u20ac<\/span><\/span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb22.1094px|0px|0px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4>Project Summary<\/h4>\n<p>People with type 1 diabetes (T1D) live with the burden of self-managing their glucose levels. Although automatic insulin delivery (AID) systems have alleviated this load, patients still need to count carbohydrates and administer insulin boluses at mealtimes, making the systems prone to human errors, which could have severe health consequences. Adjunctive therapies such as GLP-1 receptor agonists aim to mitigate these risks by reducing the impact of meals on the glucose rate of appearance in blood. These drugs are prescribed for type 2 diabetes, but they are currently being considered for their use in T1D. Simulators are one of the essential tools for developing AID systems and the foundation for digital twins, allowing testing and validating control algorithms while avoiding any risks for the patients. However, no T1D simulator includes descriptions of GLP-1 effects.<\/p>\n<p>The T1SIA project will develop a T1D simulator that includes a mathematical model of GLP-1 receptor agonists\u2019 dynamics. This 2-year project will rely on the experience of the University of Bern and the Polytechnic University of Valencia. The first year at Bern will focus on developing a GLP-1 mathematical model, supervised by an expert in AID systems and a clinician expert in adjunctive therapies. In the second year at Valencia, the model will be integrated into a T1D simulator alongside a cohort of virtual patients under the supervision of an expert in diabetes technology. T1SIA will allow exploring the contributions of these novel therapy drugs for research and product development purposes in the AID and pharmaceutical industry.<\/p>\n<p>This project will push the candidate\u2019s professional development, both for academic and industry positions, improving her knowledge of mathematical modeling, human physiology, and identifiability processes while also providing the candidate with skills in project management, networking, teaching and supervision, and communication.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb27px|0px|15px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4>Investigators<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_3,1_3,1_3&#8243; padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb0px|0px|35px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h6>Universitat Polit\u00e8cnica de Val\u00e8ncia<\/h6>\n<ul>\n<li>Jorge Bondia (coordinator)<\/li>\n<li>Clara Furi\u00f3 Novejarque<\/li>\n<\/ul>\n<h6>University of Bern<\/h6>\n<ul>\n<li>Jos\u00e9 Fernando Garc\u00eda Tirado<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][\/et_pb_column][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROJECTS &nbsp; T1SIA &nbsp; TYPE 1 DIABETES SIMULATOR WITH ADJUNCTIVE THERAPIES \u2013 GLP1Administrative Data Project Reference: HORIZON-MSCA-2024-PF-01. Proposal number: 101205486Title: T1SIA \u2013 Type 1 Diabetes Simulator with Adjunctive therapies \u2013 GLP1Participant Entities: Universitat Polit\u00e8cnica de Val\u00e8ncia, University of BernPrincipal Investigator: Jorge BondiaFunding Entity: Uni\u00f3n EuropeaDuration: 12\/01\/2026 \u2013 11\/01\/2028Funding: 243.096,72 \u20acProject Summary People with type 1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" fullwidth=\"on\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" background_color=\"#f15d2f\" custom_padding=\"30px|||\" custom_padding_tablet=\"50px|0|50px|0\" custom_padding_phone=\"\" transparent_background=\"off\" padding_mobile=\"off\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"on\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_fullwidth_code _builder_version=\"4.16\" global_colors_info=\"{}\"].[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.19.0\" _module_preset=\"default\" custom_margin=\"||-105px|||\" global_colors_info=\"{}\"][et_pb_row column_structure=\"1_4,1_2,1_4\" _builder_version=\"4.19.0\" _module_preset=\"default\" custom_margin=\"-43px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"1_4\" _builder_version=\"4.19.0\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.19.0\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_image src=\"https:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2025\/07\/MICIUCofinanciadoAEI-scaled.jpg\" alt=\"Ministerio de Econom\u00eda y c\" title_text=\"Nuevo_micin-cofinanciadoUE-aei\" _builder_version=\"4.27.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.19.0\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" min_height=\"1535.7px\" custom_padding=\"54px|0px|0px|0px\" custom_padding_tablet=\"50px|0|50px|0\" custom_padding_phone=\"\" transparent_background=\"off\" padding_mobile=\"off\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_row padding_mobile=\"off\" column_padding_mobile=\"on\" admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" text_orientation=\"center\" module_alignment=\"center\" use_border_color=\"off\" border_style=\"solid\" inline_fonts=\"Montserrat\" global_colors_info=\"{}\"]<h4><span style=\"font-family: Montserrat; color: #999999;\">PROJECTS<\/span><\/h4><br><h3>DIABETEXX<\/h3><br><p><span style=\"font-family: Montserrat; font-size: large;\">GLUCOSE CONTROL IN WOMEN VERSUS MEN: TOWARDS SEX-SPECIFIC INSULIN THERAPIES IN TYPE 1 DIABETES<\/span><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" padding_mobile=\"off\" column_padding_mobile=\"on\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_column type=\"1_2\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2025\/07\/DIABETEXX.png\" title_text=\"DIABETEXX\" align_tablet=\"center\" align_phone=\"center\" align_last_edited=\"on|desktop\" _builder_version=\"4.27.4\" animation_style=\"slide\" animation_direction=\"left\" animation_duration=\"500ms\" animation_intensity_slide=\"10%\" animation=\"left\" sticky=\"off\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" always_center_on_mobile=\"on\" global_colors_info=\"{}\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" hover_enabled=\"0\" use_border_color=\"off\" border_style=\"solid\" global_colors_info=\"{}\" sticky_enabled=\"0\"]<h4>Administrative Data<\/h4><strong>Project Reference:<\/strong> PID2022-137723OB-C21<br><strong style=\"font-size: 14px;\">Title:<\/strong><span style=\"font-size: 14px;\"> Glucose control in women versus men: towards sex-specific insulin therapies in type 1 diabetes\u00a0 - DIABETEXX\n<\/span><strong style=\"font-size: 14px;\">Participant Entities:<\/strong><span style=\"font-size: 14px;\"> Co-ordinated Project\n<\/span><strong style=\"font-size: 14px;\">Subproject 1:<\/strong><span style=\"font-size: 14px;\"> Universitat Polit\u00e8cnica de Val\u00e8ncia (co-ordinator)\n<\/span><strong style=\"font-size: 14px;\">Subproject 2:<\/strong><span style=\"font-size: 14px;\"> Universitat de Girona\n<\/span><strong style=\"font-size: 14px;\">Principal Investigator:<\/strong><span style=\"font-size: 14px;\"> Jorge Bondia, Jos\u00e9 Luis D\u00edez (co-ordinadors); Josep Veh\u00ed\n<strong style=\"font-size: 14px;\">Funding Entity:<\/strong><span style=\"font-size: 14px;\"> Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Agencia Estatal de Investigaci\u00f3n, FEDER\n<\/span><strong style=\"font-size: 14px;\">Duration:<\/strong><span style=\"font-size: 14px;\"> 01\/09\/2023-31\/08\/2026\n<\/span><strong style=\"font-size: 14px;\">Funding:<\/strong><span style=\"font-size: 14px;\"> Subproject 1: \u20ac215,000.00\n<\/span><span style=\"font-size: 14px;\">Subproject 2: \u20ac206,250.00<\/span><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\"off\" column_padding_mobile=\"on\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"22.1094px|0px|0px|0px\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" hover_enabled=\"0\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" global_colors_info=\"{}\" sticky_enabled=\"0\"]<h4>Project Summary<\/h4>\n<p>There is growing evidence that sex and gender affect the pathophysiology, incidence, prevalence, development and response to therapy in many diseases. This is the case of diabetes, where factors such as differences in lifestyle (diet and exercise), sex hormones and body composition, produce differences in glucose regulation between women and men, leading to poorer glycaemic control in women. Consequently, women with type 1 diabetes have an additional 37% risk of death, and twice the excess risk of suffering vascular events as compared to men. On the other hand, some studies have shown the influence of menstrual cycle phase in glucose control in fertile women, changes in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes.<\/p>\n<p>Despite technological advancements in the market, such are artificial pancreas or smart insulin pens for multiple insulin dose (MDI) therapies, there is still an unmet need of to improve blood glucose control in people with type 1 diabetes and sex differences are not considered. Women consistently report bigger challenges in controlling their glycemia due to menstrual cycle changes, and differences in glucose regulation between healthy women and men do exist and are not translated into technology.<\/p>\n<p>The project hypothesis is that sex-based personalization of insulin therapies will translate into a better blood glucose control, especially among women with a better counteraction of menstrual cycle effects. Then, the overall goal of this project is the personalization of insulin therapy according to physiological differences in women and men for a better blood glucose control. Emphasis will be put in the development of new decision support systems for MDI therapy incorporating real-time monitoring of menstrual cycle phases in women. Evaluation of the need of sex-specific control algorithms for the artificial pancreas will also be carried out, as well as proof-of-concept simulation study evaluating a sex-specific version of our artificial pancreas. To reach the objective and obtain the desired technological results, firstly, beyond-state-of-the-art knowledge will be generated about the influence of the menstrual cycle phase (follicular vs. luteal) on the use of artificial pancreas and on the glycaemic effect of exercise and meals, the two most important disturbances in glucose control, thanks to 3 clinical studies. Secondly, new physiological exercise and meal models, incorporating the new findings will be developed. These models will serve to develop new simulation tools able to describe sex differences in blood glucose control, beyond insulin sensitivity changes among phases. Specific cohorts of virtual patients will be generated incorporating the physiological models developed in the project as well as specific scenarios for each sub-population. Additionally, new data-driven models based on machine learning techniques will be used for the generation of in silico virtual patients to complement the physiological models. Finally, a new dedicated wearable technology will also be built and validated for real-time monitoring of relevant menstrual cycle phases information. for its integration into decision support systems for MDI users and artificial pancreas systems. Apart from its future integration in decision support systems for MDI users and artificial pancreas systems, the device could be used in many other applications in the future.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\"off\" column_padding_mobile=\"on\" admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"27px|0px|15px|0px\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" use_border_color=\"off\" border_style=\"solid\" global_colors_info=\"{}\"]<h4>Investigators<\/h4>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" padding_mobile=\"off\" column_padding_mobile=\"on\" admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"0px|0px|35px|0px\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"off\" custom_width_px=\"1080px\" custom_width_percent=\"80%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" hover_enabled=\"0\" use_border_color=\"off\" global_colors_info=\"{}\" sticky_enabled=\"0\"]<h6>Universitat Polit\u00e8cnica de Val\u00e8ncia<\/h6>\n<ul>\n<li>Jorge Bondia (co-ordinator)<\/li>\n<li>Jos\u00e9 Luis D\u00edez (co-ordinator)<\/li>\n<li>Sergio Romero<\/li>\n<li>Pedro Jos\u00e9 Garc\u00eda<\/li>\n<li>Jos\u00e9 Manuel Terr\u00e9s<\/li>\n<li>Nerea Albadalejo<\/li>\n<li>Mar\u00eda Teresa Mendoza<\/li>\n<\/ul>\n<h6>Universitat de Val\u00e8ncia<\/h6>\n<ul>\n<li>Rodrigo Mart\u00edn San Agust\u00edn<\/li>\n<\/ul>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" hover_enabled=\"0\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" global_colors_info=\"{}\" sticky_enabled=\"0\"]<h6>Universitat de Girona<\/h6><ul>\n<li>Josep Veh\u00ed (co-PI)<\/li>\n<li>Ningsu Luo<\/li>\n<li>Remei Calm<\/li>\n<li>Omer Mujahid<\/li>\n<li>Ernesto Estremera<\/li>\n<li>Aleix Beneyto<\/li>\n<\/ul>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.27.4\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" hover_enabled=\"0\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" global_colors_info=\"{}\" sticky_enabled=\"0\"]<h6>Hospital Universitario Ram\u00f3n y Cajal<\/h6><ul>\n<li>Ane Bayona<\/li>\n<li>Esther de la Calle<\/li>\n<\/ul><p>\n<\/p><h6>Hospital Universitari i Polit\u00e8cnic La Fe<\/h6><ul>\n<li>Paolo Rossetti<\/li>\n<\/ul><p><\/p><h6>Hospital Cl\u00ednico de Valencia<\/h6><ul>\n<li>F. Javier Ampudia<\/li>\n<\/ul><h6>\nHospital Cl\u00ednic de Barcelona<\/h6><ul>\n<li>Ignacio Conget<\/li>\n<li>Marga Gim\u00e9nez<\/li>\n<\/ul>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3813","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>T1SIA - Tecnodiabetes<\/title>\n<meta name=\"description\" content=\"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T1SIA - Tecnodiabetes\" \/>\n<meta property=\"og:description\" content=\"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Tecnodiabetes\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Tecnodiabetes-1788690764738148\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-03T19:17:44+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@tecnodiabetes\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/index.php\\\/t1sia\\\/?lang=en\",\"url\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/index.php\\\/t1sia\\\/?lang=en\",\"name\":\"T1SIA - Tecnodiabetes\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/#website\"},\"datePublished\":\"2026-02-02T15:51:23+00:00\",\"dateModified\":\"2026-02-03T19:17:44+00:00\",\"description\":\"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/index.php\\\/t1sia\\\/?lang=en#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/index.php\\\/t1sia\\\/?lang=en\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/index.php\\\/t1sia\\\/?lang=en#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"T1SIA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/#website\",\"url\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/\",\"name\":\"Tecnodiabetes\",\"description\":\"Divulgaci\u00f3n Cient\u00edfica sobre Diabetes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/tecnodiabetes.ai2.upv.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"T1SIA - Tecnodiabetes","description":"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en","og_locale":"es_ES","og_type":"article","og_title":"T1SIA - Tecnodiabetes","og_description":"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator","og_url":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en","og_site_name":"Tecnodiabetes","article_publisher":"https:\/\/www.facebook.com\/Tecnodiabetes-1788690764738148\/","article_modified_time":"2026-02-03T19:17:44+00:00","twitter_card":"summary_large_image","twitter_site":"@tecnodiabetes","twitter_misc":{"Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en","url":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en","name":"T1SIA - Tecnodiabetes","isPartOf":{"@id":"https:\/\/tecnodiabetes.ai2.upv.es\/#website"},"datePublished":"2026-02-02T15:51:23+00:00","dateModified":"2026-02-03T19:17:44+00:00","description":"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator","breadcrumb":{"@id":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/t1sia\/?lang=en#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/tecnodiabetes.ai2.upv.es\/"},{"@type":"ListItem","position":2,"name":"T1SIA"}]},{"@type":"WebSite","@id":"https:\/\/tecnodiabetes.ai2.upv.es\/#website","url":"https:\/\/tecnodiabetes.ai2.upv.es\/","name":"Tecnodiabetes","description":"Divulgaci\u00f3n Cient\u00edfica sobre Diabetes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/tecnodiabetes.ai2.upv.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"}]}},"_links":{"self":[{"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/pages\/3813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/comments?post=3813"}],"version-history":[{"count":10,"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/pages\/3813\/revisions"}],"predecessor-version":[{"id":3839,"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/pages\/3813\/revisions\/3839"}],"wp:attachment":[{"href":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/wp-json\/wp\/v2\/media?parent=3813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}