{"id":3421,"date":"2025-07-09T17:40:28","date_gmt":"2025-07-09T15:40:28","guid":{"rendered":"https:\/\/tecnodiabetes.ai2.upv.es\/?page_id=3421"},"modified":"2025-07-09T17:40:30","modified_gmt":"2025-07-09T15:40:30","slug":"diabetexx","status":"publish","type":"page","link":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/diabetexx\/?lang=en","title":{"rendered":"DIABETEXX"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; fullwidth=\u00bbon\u00bb custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#f15d2f\u00bb custom_padding=\u00bb30px|||\u00bb custom_padding_tablet=\u00bb50px|0|50px|0&#8243; custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bbon\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_fullwidth_code _builder_version=\u00bb4.16&#8243; 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_module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.19.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16&#8243; min_height=\u00bb1535.7px\u00bb custom_padding=\u00bb54px|0px|0px|0px\u00bb custom_padding_tablet=\u00bb50px|0|50px|0&#8243; custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb text_orientation=\u00bbcenter\u00bb module_alignment=\u00bbcenter\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb inline_fonts=\u00bbMontserrat\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4><span style=\"font-family: Montserrat; color: #999999;\">PROJECTS<\/span><\/h4>\n<p><\/p>\n<h3>DIABETEXX<\/h3>\n<p><\/p>\n<p><span style=\"font-family: Montserrat; font-size: large;\">GLUCOSE CONTROL IN WOMEN VERSUS MEN: TOWARDS SEX-SPECIFIC INSULIN THERAPIES IN TYPE 1 DIABETES<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2&#8243; padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2025\/07\/DIABETEXX.png\u00bb title_text=\u00bbDIABETEXX\u00bb align_tablet=\u00bbcenter\u00bb align_phone=\u00bbcenter\u00bb align_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.27.4&#8243; animation_style=\u00bbslide\u00bb animation_direction=\u00bbleft\u00bb animation_duration=\u00bb500ms\u00bb animation_intensity_slide=\u00bb10%\u00bb animation=\u00bbleft\u00bb sticky=\u00bboff\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb always_center_on_mobile=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb hover_enabled=\u00bb0&#8243; use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h4>Administrative Data<\/h4>\n<p><strong>Project Reference:<\/strong> PID2022-137723OB-C21<br \/><strong style=\"font-size: 14px;\">Title:<\/strong><span style=\"font-size: 14px;\"> Glucose control in women versus men: towards sex-specific insulin therapies in type 1 diabetes\u00a0 &#8211; DIABETEXX<br \/>\n<\/span><strong style=\"font-size: 14px;\">Participant Entities:<\/strong><span style=\"font-size: 14px;\"> Co-ordinated Project<br \/>\n<\/span><strong style=\"font-size: 14px;\">Subproject 1:<\/strong><span style=\"font-size: 14px;\"> Universitat Polit\u00e8cnica de Val\u00e8ncia (co-ordinator)<br \/>\n<\/span><strong style=\"font-size: 14px;\">Subproject 2:<\/strong><span style=\"font-size: 14px;\"> Universitat de Girona<br \/>\n<\/span><strong style=\"font-size: 14px;\">Principal Investigator:<\/strong><span style=\"font-size: 14px;\"> Jorge Bondia, Jos\u00e9 Luis D\u00edez (co-ordinadors); Josep Veh\u00ed<br \/>\n<strong style=\"font-size: 14px;\">Funding Entity:<\/strong><span style=\"font-size: 14px;\"> Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Agencia Estatal de Investigaci\u00f3n, FEDER<br \/>\n<\/span><strong style=\"font-size: 14px;\">Duration:<\/strong><span style=\"font-size: 14px;\"> 01\/09\/2023-31\/08\/2026<br \/>\n<\/span><strong style=\"font-size: 14px;\">Funding:<\/strong><span style=\"font-size: 14px;\"> Subproject 1: \u20ac215,000.00<br \/>\n<\/span><span style=\"font-size: 14px;\">Subproject 2: \u20ac206,250.00<\/span><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb22.1094px|0px|0px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb hover_enabled=\u00bb0&#8243; use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h4>Project Summary<\/h4>\n<p>There is growing evidence that sex and gender affect the pathophysiology, incidence, prevalence, development and response to therapy in many diseases. This is the case of diabetes, where factors such as differences in lifestyle (diet and exercise), sex hormones and body composition, produce differences in glucose regulation between women and men, leading to poorer glycaemic control in women. Consequently, women with type 1 diabetes have an additional 37% risk of death, and twice the excess risk of suffering vascular events as compared to men. On the other hand, some studies have shown the influence of menstrual cycle phase in glucose control in fertile women, changes in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes.<\/p>\n<p>Despite technological advancements in the market, such are artificial pancreas or smart insulin pens for multiple insulin dose (MDI) therapies, there is still an unmet need of to improve blood glucose control in people with type 1 diabetes and sex differences are not considered. Women consistently report bigger challenges in controlling their glycemia due to menstrual cycle changes, and differences in glucose regulation between healthy women and men do exist and are not translated into technology.<\/p>\n<p>The project hypothesis is that sex-based personalization of insulin therapies will translate into a better blood glucose control, especially among women with a better counteraction of menstrual cycle effects. Then, the overall goal of this project is the personalization of insulin therapy according to physiological differences in women and men for a better blood glucose control. Emphasis will be put in the development of new decision support systems for MDI therapy incorporating real-time monitoring of menstrual cycle phases in women. Evaluation of the need of sex-specific control algorithms for the artificial pancreas will also be carried out, as well as proof-of-concept simulation study evaluating a sex-specific version of our artificial pancreas. To reach the objective and obtain the desired technological results, firstly, beyond-state-of-the-art knowledge will be generated about the influence of the menstrual cycle phase (follicular vs. luteal) on the use of artificial pancreas and on the glycaemic effect of exercise and meals, the two most important disturbances in glucose control, thanks to 3 clinical studies. Secondly, new physiological exercise and meal models, incorporating the new findings will be developed. These models will serve to develop new simulation tools able to describe sex differences in blood glucose control, beyond insulin sensitivity changes among phases. Specific cohorts of virtual patients will be generated incorporating the physiological models developed in the project as well as specific scenarios for each sub-population. Additionally, new data-driven models based on machine learning techniques will be used for the generation of in silico virtual patients to complement the physiological models. Finally, a new dedicated wearable technology will also be built and validated for real-time monitoring of relevant menstrual cycle phases information. for its integration into decision support systems for MDI users and artificial pancreas systems. Apart from its future integration in decision support systems for MDI users and artificial pancreas systems, the device could be used in many other applications in the future.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb27px|0px|15px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4>Investigators<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_3,1_3,1_3&#8243; padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb0px|0px|35px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb hover_enabled=\u00bb0&#8243; use_border_color=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h6>Universitat Polit\u00e8cnica de Val\u00e8ncia<\/h6>\n<ul>\n<li>Jorge Bondia (co-ordinator)<\/li>\n<li>Jos\u00e9 Luis D\u00edez (co-ordinator)<\/li>\n<li>Sergio Romero<\/li>\n<li>Pedro Jos\u00e9 Garc\u00eda<\/li>\n<li>Jos\u00e9 Manuel Terr\u00e9s<\/li>\n<li>Nerea Albadalejo<\/li>\n<li>Mar\u00eda Teresa Mendoza<\/li>\n<\/ul>\n<h6>Universitat de Val\u00e8ncia<\/h6>\n<ul>\n<li>Rodrigo Mart\u00edn San Agust\u00edn<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb hover_enabled=\u00bb0&#8243; use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h6>Universitat de Girona<\/h6>\n<ul>\n<li>Josep Veh\u00ed (co-PI)<\/li>\n<li>Ningsu Luo<\/li>\n<li>Remei Calm<\/li>\n<li>Omer Mujahid<\/li>\n<li>Ernesto Estremera<\/li>\n<li>Aleix Beneyto<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb hover_enabled=\u00bb0&#8243; use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h6>Hospital Universitario Ram\u00f3n y Cajal<\/h6>\n<ul>\n<li>Ane Bayona<\/li>\n<li>Esther de la Calle<\/li>\n<\/ul>\n<h6>Hospital Universitari i Polit\u00e8cnic La Fe<\/h6>\n<ul>\n<li>Paolo Rossetti<\/li>\n<\/ul>\n<h6>Hospital Cl\u00ednico de Valencia<\/h6>\n<ul>\n<li>F. Javier Ampudia<\/li>\n<\/ul>\n<h6>\nHospital Cl\u00ednic de Barcelona<\/h6>\n<ul>\n<li>Ignacio Conget<\/li>\n<li>Marga Gim\u00e9nez<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROJECTSDIABETEXXGLUCOSE CONTROL IN WOMEN VERSUS MEN: TOWARDS SEX-SPECIFIC INSULIN THERAPIES IN TYPE 1 DIABETESAdministrative DataProject Reference: PID2022-137723OB-C21Title: Glucose control in women versus men: towards sex-specific insulin therapies in type 1 diabetes\u00a0 &#8211; DIABETEXX Participant Entities: Co-ordinated Project Subproject 1: Universitat Polit\u00e8cnica de Val\u00e8ncia (co-ordinator) Subproject 2: Universitat de Girona Principal Investigator: Jorge Bondia, Jos\u00e9 Luis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3421","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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