{"id":3069,"date":"2023-09-10T19:42:49","date_gmt":"2023-09-10T17:42:49","guid":{"rendered":"https:\/\/tecnodiabetes.ai2.upv.es\/?page_id=3069"},"modified":"2025-09-18T14:14:23","modified_gmt":"2025-09-18T12:14:23","slug":"diabetexx","status":"publish","type":"page","link":"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/diabetexx\/","title":{"rendered":"DIABETEXX"},"content":{"rendered":"

[et_pb_section fb_built=\u00bb1″ fullwidth=\u00bbon\u00bb custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16″ background_color=\u00bb#f15d2f\u00bb custom_padding=\u00bb30px|||\u00bb custom_padding_tablet=\u00bb50px|0|50px|0″ custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bbon\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_fullwidth_code _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb].[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.19.0″ _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||-105px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb1_4,1_2,1_4″ _builder_version=\u00bb4.19.0″ _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb-43px|auto||auto||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_4″ _builder_version=\u00bb4.19.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.19.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2025\/07\/MICIUCofinanciadoAEI-scaled.jpg\u00bb alt=\u00bbMinisterio de Econom\u00eda y c\u00bb title_text=\u00bbNuevo_micin-cofinanciadoUE-aei\u00bb _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_4″ _builder_version=\u00bb4.19.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ custom_padding_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.16″ min_height=\u00bb1535.7px\u00bb custom_padding=\u00bb54px|0px|0px|0px\u00bb custom_padding_tablet=\u00bb50px|0|50px|0″ custom_padding_phone=\u00bb\u00bb transparent_background=\u00bboff\u00bb padding_mobile=\u00bboff\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb text_orientation=\u00bbcenter\u00bb module_alignment=\u00bbcenter\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb inline_fonts=\u00bbMontserrat\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

PROYECTOS<\/span><\/h4>\n

DIABETEXX<\/h3>\n

CONTROL DE GLUCOSA EN MUJERES VERSUS HOMBRES: HACIA TERAPIAS DE INSULINA ESPEC\u00cdFICAS POR SEXO EN DIABETES TIPO 1<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2″ padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/tecnodiabetes.ai2.upv.es\/wp-content\/uploads\/2025\/07\/DIABETEXX.png\u00bb title_text=\u00bbDIABETEXX\u00bb align_tablet=\u00bbcenter\u00bb align_phone=\u00bbcenter\u00bb align_last_edited=\u00bbon|desktop\u00bb _builder_version=\u00bb4.27.4″ animation_style=\u00bbslide\u00bb animation_direction=\u00bbleft\u00bb animation_duration=\u00bb500ms\u00bb animation_intensity_slide=\u00bb10%\u00bb animation=\u00bbleft\u00bb sticky=\u00bboff\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb always_center_on_mobile=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Datos administrativos<\/h4>\n

Referencia del proyecto:<\/strong> PID2022-137723OB-C21
\nT\u00edtulo:<\/strong> Control de glucosa en mujeres versus hombres: hacia terapias de insulina espec\u00edficas por sexo en diabetes tipo 1\u00a0 – DIABETEXX
\n<\/span>Entidades participantes:<\/strong> Proyecto coordinado
\n<\/span>Subproyecto 1:<\/strong> Universitat Polit\u00e8cnica de Val\u00e8ncia (coordinador)
\n<\/span>Subproyecto 2:<\/strong> Universitat de Girona
\n<\/span>Investigador principal:<\/strong> Jorge Bondia, Jos\u00e9 Luis D\u00edez (coordinadores); Josep Veh\u00ed
\nEntidad financiadora:<\/strong> Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Agencia Estatal de Investigaci\u00f3n, FEDER
\n<\/span>Duraci\u00f3n:<\/strong> 01\/09\/2023-31\/08\/2026
\n<\/span>Financiaci\u00f3n recibida:<\/strong> Subproyecto 1: 215.000,00\u20ac
\n<\/span>Subproyecto 2: 206.250,00\u20ac<\/span><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb22.1094px|0px|0px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Resumen del proyecto<\/h4>\n

Cada vez hay m\u00e1s pruebas de que el sexo y el g\u00e9nero afectan a la fisiopatolog\u00eda, la incidencia, la prevalencia, el desarrollo y la respuesta al tratamiento de muchas enfermedades. Este es el caso de la diabetes, en la que factores como las diferencias en el estilo de vida (dieta y ejercicio), las hormonas sexuales y la composici\u00f3n corporal, producen diferencias en la regulaci\u00f3n de la glucosa entre mujeres y hombres, lo que lleva a un peor control gluc\u00e9mico en las mujeres. En consecuencia, las mujeres con diabetes tipo 1 tienen un 37% m\u00e1s de riesgo de muerte y el doble de riesgo de sufrir eventos vasculares que los hombres. Por otra parte, algunos estudios han puesto de manifiesto la influencia de la fase del ciclo menstrual en el control de la glucosa en mujeres f\u00e9rtiles, as\u00ed como cambios en la sensibilidad a la insulina entre las fases folicular y l\u00fatea en mujeres con diabetes de tipo 1.<\/p>\n

A pesar de los avances tecnol\u00f3gicos del mercado, como el p\u00e1ncreas artificial o las plumas de insulina inteligentes para terapias con dosis m\u00faltiples de insulina (MDI), sigue habiendo una necesidad insatisfecha de mejorar el control de la glucemia en personas con diabetes tipo 1 y no se tienen en cuenta las diferencias de sexo. Las mujeres manifiestan sistem\u00e1ticamente mayores dificultades para controlar su glucemia debido a los cambios del ciclo menstrual, y existen diferencias en la regulaci\u00f3n de la glucosa entre mujeres y hombres sanos que no se traducen en tecnolog\u00eda.<\/p>\n

La hip\u00f3tesis del proyecto es que la personalizaci\u00f3n de las terapias de insulina en funci\u00f3n del sexo se traducir\u00e1 en un mejor control de la glucemia, especialmente entre las mujeres, que podr\u00e1n contrarrestar mejor los efectos del ciclo menstrual. Entonces, el objetivo general de este proyecto es la personalizaci\u00f3n de la terapia de insulina seg\u00fan las diferencias fisiol\u00f3gicas en mujeres y hombres para un mejor control de la glucemia. Se har\u00e1 hincapi\u00e9 en el desarrollo de nuevos sistemas de apoyo a la toma de decisiones para la terapia con IDM
\nque incorporen la monitorizaci\u00f3n en tiempo real de las fases del ciclo menstrual en las mujeres. Tambi\u00e9n se llevar\u00e1 a cabo una evaluaci\u00f3n de la necesidad de algoritmos de control espec\u00edficos para cada sexo para el p\u00e1ncreas artificial, as\u00ed como un estudio de simulaci\u00f3n de prueba de concepto que eval\u00fae una versi\u00f3n espec\u00edfica para cada sexo de nuestro p\u00e1ncreas artificial.<\/p>\n

Para alcanzar el objetivo y obtener los resultados tecnol\u00f3gicos deseados, en primer lugar, se generar\u00e1n conocimientos de vanguardia sobre la influencia de la fase del ciclo menstrual (folicular frente a l\u00fatea) en el uso del p\u00e1ncreas artificial y sobre el efecto gluc\u00e9mico del ejercicio y las comidas, las dos alteraciones m\u00e1s importantes en el control de la glucosa, gracias a 3 estudios cl\u00ednicos. En segundo lugar, se desarrollar\u00e1n nuevos modelos fisiol\u00f3gicos de ejercicio y comidas que incorporen los nuevos hallazgos. Estos modelos servir\u00e1n para desarrollar nuevas herramientas de simulaci\u00f3n capaces de describir las diferencias de sexo en el control de la glucemia, m\u00e1s all\u00e1 de los cambios de sensibilidad a la insulina entre fases. Se generar\u00e1n cohortes espec\u00edficas de pacientes virtuales que incorporar\u00e1n los modelos fisiol\u00f3gicos desarrollados en el proyecto, as\u00ed como escenarios espec\u00edficos para cada subpoblaci\u00f3n. Adem\u00e1s, se utilizar\u00e1n nuevos modelos basados en datos y en t\u00e9cnicas de aprendizaje autom\u00e1tico para generar pacientes virtuales in silico que complementen los modelos fisiol\u00f3gicos.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb27px|0px|15px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Investigadores<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_3,1_3,1_3″ padding_mobile=\u00bboff\u00bb column_padding_mobile=\u00bbon\u00bb admin_label=\u00bbrow\u00bb _builder_version=\u00bb4.16″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb custom_padding=\u00bb0px|0px|35px|0px\u00bb make_fullwidth=\u00bboff\u00bb use_custom_width=\u00bboff\u00bb width_unit=\u00bboff\u00bb custom_width_px=\u00bb1080px\u00bb custom_width_percent=\u00bb80%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Universitat Polit\u00e8cnica de Val\u00e8ncia<\/h6>\n
    \n
  • Jorge Bondia (coordinador)<\/li>\n
  • Jos\u00e9 Luis D\u00edez (coordinador)<\/li>\n
  • Sergio Romero<\/li>\n
  • Pedro Jos\u00e9 Garc\u00eda<\/li>\n
  • Jos\u00e9 Manuel Terr\u00e9s<\/li>\n
  • Nerea Albaladejo<\/li>\n
  • Mar\u00eda Teresa Mendoza<\/li>\n<\/ul>\n
    Universitat de Val\u00e8ncia<\/h6>\n
      \n
    • Rodrigo Mart\u00edn San Agust\u00edn<\/li>\n<\/ul>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

      Universitat de Girona<\/h6>\n
        \n
      • Josep Veh\u00ed (co-IP)<\/li>\n
      • Ningsu Luo<\/li>\n
      • Remei Calm<\/li>\n
      • Omer Mujahid<\/li>\n
      • Ernesto Estremera<\/li>\n
      • Aleix Beneyto<\/li>\n<\/ul>\n

        [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ background_size=\u00bbinitial\u00bb background_position=\u00bbtop_left\u00bb background_repeat=\u00bbrepeat\u00bb use_border_color=\u00bboff\u00bb border_color=\u00bb#ffffff\u00bb border_style=\u00bbsolid\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

        \nHospital Universitario Ram\u00f3n y Cajal<\/h6>\n
          \n
        • Ane Bayona<\/li>\n
        • Esther de la Calle<\/li>\n<\/ul>\n
          Hospital Universitari i Polit\u00e8cnic La Fe<\/h6>\n
            \n
          • Paolo Rossetti<\/li>\n<\/ul>\n
            Hospital Cl\u00ednico de Valencia<\/h6>\n
              \n
            • F. Javier Ampudia<\/li>\n<\/ul>\n
              \nHospital Cl\u00ednic de Barcelona<\/h6>\n
                \n
              • Ignacio Conget<\/li>\n
              • Marga Gim\u00e9nez<\/li>\n<\/ul>\n

                [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

                PROYECTOS DIABETEXX CONTROL DE GLUCOSA EN MUJERES VERSUS HOMBRES: HACIA TERAPIAS DE INSULINA ESPEC\u00cdFICAS POR SEXO EN DIABETES TIPO 1Datos administrativos Referencia del proyecto: PID2022-137723OB-C21 T\u00edtulo: Control de glucosa en mujeres versus hombres: hacia terapias de insulina espec\u00edficas por sexo en diabetes tipo 1\u00a0 – DIABETEXX Entidades participantes: Proyecto coordinado Subproyecto 1: Universitat Polit\u00e8cnica de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3069","page","type-page","status-publish","hentry"],"yoast_head":"\nDIABETEXX - Tecnodiabetes<\/title>\n<meta name=\"description\" content=\"diabetes, tecnolog\u00eda, investigaci\u00f3n, innovaci\u00f3n, diabetes tipo 1, diabetes tipo 2, p\u00e1ncreas artificial, bomba de insulina, monitor continuo de glucosa, glucosa, insulina, educaci\u00f3n diabetes, simulador diabetes, robot diabetes, CSII, MDI, SAP, CGM, type 1 diabetes, type 2 diabetes, artificial pancreas, insulin pump, continuous glucose monitor, glucose, insulin, diabetes education, diabetes simulator\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tecnodiabetes.ai2.upv.es\/index.php\/diabetexx\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DIABETEXX - 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